Mining Surveillance Data: Does Radiation Treatment of Prostate Cancer Cause Rectal Cancer?

John W. Morgan, Brice Jabo, Mark E. Ghamsary, Kevork Kazanjian


Prostate cancer (PC) is the most common invasive cancer among males, with most cases organ-confined at diagnosis. External beam radiation (RAD) and prostatectomy (SURG) represent the most common treatments for organ-confined PC, with RAD exposing the rectum to high-dose ionizing radiation. Using the California population for 1988-2009, we identified men treated with RAD and SURG for organ-confined PC and assessed the hazards ratio for rectal cancer five or more years following PC treatment. The adjusted Cox proportional hazards ratio was 39% higher for rectal cancer in the RAD cohort. Further analyses seek to distinguish roles of RAD dose and delivery.

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Online Journal of Public Health Informatics * ISSN 1947-2579 *