OJPHI: Vol. 5
Journal Information
Journal ID (publisher-id): OJPHI
ISSN: 1947-2579
Publisher: University of Illinois at Chicago Library
Article Information
©2013 the author(s)
open-access: This is an Open Access article. Authors own copyright of their articles appearing in the Online Journal of Public Health Informatics. Readers may copy articles without permission of the copyright owner(s), as long as the author and OJPHI are acknowledged in the copy and the copy is used for educational, not-for-profit purposes.
Electronic publication date: Day: 4 Month: 4 Year: 2013
collection publication date: Year: 2013
Volume: 5E-location ID: e107
Publisher Id: ojphi-05-107

Statistical Models for Biosurveillance of Multiple Organisms
Doyo G. Enki*1
Angela Noufaily1
C. P. Farrington1
Paul H. Garthwaite1
Nick Andrews2
André Charlett2
Chris Lane2
1Mathematics and Statistics, The Open University, Milton Keynes, United Kingdom;
2Health Protection Agency, London, United Kingdom
*Doyo G. Enki, E-mail: d.gragn@open.ac.uk

Abstract
Objective

To look at the diversity of the patterns displayed by a range of organisms, and to seek a simple family of models that adequately describes all organisms, rather than a well-fitting model for any particular organism.

Introduction

There has been much research on statistical methods of prospective outbreak detection that are aimed at identifying unusual clusters of one syndrome or disease, and some work on multivariate surveillance methods (1). In England and Wales, automated laboratory surveillance of infectious diseases has been undertaken since the early 1990’s. The statistical methodology of this automated system is described in (2). However, there has been little research on outbreak detection methods that are suited to large, multiple surveillance systems involving thousands of different organisms.

Methods

We obtained twenty years’ data on weekly counts of all infectious disease organisms reported to the UK’s Health Protection Agency. We summarized the mean frequencies, trends and seasonality of each organism using log-linear models. To identify a simple family of models which adequately represents all organisms, the Poisson model, the quasi-Poisson model and the negative binomial model were investigated (3,4). Formal goodness-of-fit tests were not used as they can be unreliable with sparse data. Adequacy of the models was empirically studied using the relationships between the mean, variance and skewness. For this purpose, each data series was first subdivided into 41 half-years and de-seasonalized.

Results

Trends and seasonality were summarized by plotting the distribution of estimated linear trend parameters for 2250 organisms, and modal seasonal period for 2254 organisms, including those organisms for which the seasonal effect is statistically significant.

Relationships between mean and variance were summarized as given in Figure 1.

Similar plots were used to summarize the relationships between mean and skewness.

Conclusions

Statistical outbreak detection models must be able to cope with seasonality and trends. The data analyses suggest that the great majority of organisms can adequately – though far from perfectly – be represented by a statistical model in which the variance is proportional to the mean, such as the quasi-Poisson or negative binomial models.


Acknowledgments

This research was supported by a project grant from the UK Medical Research Council, and by a Royal Society Wolfson Research Merit Award.


References
1.. Unkel S, Farrington CP, Garthwaite PH, Robertson C, Andrews N. Statistical methods for the prospective detection of infectious disease outbreaks: a reviewJ R Statist Soc A 2012;175:49–82.
2.. Farrington CP, Andrews NJ, Beale AD, Catchpole MA. A statistical algorithm for the early detection of outbreaks of infectious diseaseJ R Statist Soc A 1996;159:547–563.
3.. McCullagh P, Nelder JA. Generalized Linear Models (2nd ed). 2nd ed. London: Chapman & Hall; 1989
4.. Hastie TJ, Tibshirani RJ. Generalized Additive Models. London: Chapman & Hall; 1990
Figure

Figures
ojphi-05-107f1.tif
[Figure ID: f1-ojphi-05-107]
Figure 1 

Relationships between mean and variance. (top) Histogram of the slopes of the best fit lines for 1001 organisms; the value 1 corresponds to the quasi-Poisson model; (bottom) log of variance plotted against log of mean for one organism. The full line is the best fit to the points; the dashed line corresponds to the quasi-Poisson model; the dotted line corresponds to the Poisson model.



Article Categories:
  • ISDS 2012 Conference Abstracts

Keywords: Biosurveillance, Public Health Surveillance, Data Analysis, Infectious Disease Outbreaks, Statistical Model.




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